IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection

IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection

BACKGROUND & AIMS Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during Helicobacter pylori infection. Here, we delineate the role of IL33 in the normal gastric mucosa and in response to gastropathy. METHODS IL33 expression was evaluated in mice and human biopsy specimens infecte...

Why Believe That There Is a God?

This article presents an argument for the existence of God, showing that the evident phenomena are best explained by supposing that a God causes them. The argument is based on the inductive force of four very evident general phenomena: that there is a physical Universe; that it is governed by very simple natural laws; that those laws are such as to lead to the existence of human bodies; and tha...

a comparison of teachers and supervisors, with respect to teacher efficacy and reflection

supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...

Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response

BACKGROUND Ascariasis remains the most common helminth infection in humans. As an alternative or complementary approach to global deworming, a pan-anthelminthic vaccine is under development targeting Ascaris, hookworm, and Trichuris infections. As16 and As14 have previously been described as two genetically related proteins from Ascaris suum that induced protective immunity in mice when formula...

“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries